Antioxidant and gastroprotective effects of the ethyl acetate extract from Stemodia maritima L. in ethanol-induced gastric ulcer model

Stemodia maritima L., is a shrub of the Plantaginaceae family, with some biological activities already described, such as: larvicide, antimicrobial, and anti-inflammatory. Thus, objective this work was to evaluate antioxidant, gastroprotective ethyl acetate extract from S. maritima. The phytochemical profile investigated through quantification total phenolic compounds, flavonoids, CCD analysis. toxicity performed cell viability using L929 line cell, acute by OECD Guide 423. antioxidant activity analyzed methods reduction ferric ion (FRAP), (TAA), absolute ethanol-induced gastric ulcer model, analysis NO, MDA, GSH MPO levels in stomach tissues. In it possible identify presence triterpenes, steroids, mono, sesquiterpenes. not cytotoxic against lineage, maintaining above 70% at doses tested, did show physiological changes indicative compared control group. presented 157.3 ± 9.7 mg equivalent Trolox/g FRAP method, 50.0 1.1 % TAA. maritima, reduced ulcerative lesion index injured group, increased NO GSH, able decrease concentrations MDA MPO, enhancing their activity.